Stabilising Peptides to Unlock New Dimensions in Precision Targeting for Cell Entry & Beyond
Time: 9:45 am
day: Conference Day 2
Details:
- Stabilising the peptide’s alpha-helical structure, enhancing its rigidity and resistance to proteolytic degradation, which improves its ability to penetrate cell membranes
- Achieving stabilisation through modifications such as hydrocarbon stapling or incorporating unnatural amino acids, helping to maintain structural integrity and functional activity inside the cell
- Improving the peptide pharmacokinetic properties through the addition of hydrophilic groups and cyclic constraints, which reduce renal clearance and enhance the peptides’ stability in the bloodstream
